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KMID : 0984720030350040215
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Infection and Chemotherapy
2003 Volume.35 No. 4 p.215 ~ p.220
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Severe Chronic Active Epstein-Barr Virus Infection Presenting as Fever of Unknown Origin
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Jeon Kyeong-Man
Kim Eung-Ho
Son Jun-Seong
Chang Hyun-Ha
Jung Sook-In
Oh Won-Sup
Peck Kyong-Ran
Song Jae-Hoon
Koh Kwang-Cheol
Jung Chul-Won
Ko Young-Hyeh
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Abstract
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Epstein-Barr virus (EBV) is one of eight human herpesvirus. Primary infection with EBV in childhood is generally asymptomatic or mild, however, often causes overt diseases such as infectious mononucleosis (IM) and Iymphop roliferative disorder (LPD), the latter occursing in immunologically compromised individuals. Historically, EBV has been considered to be etiologically linked to human malignancies such as EBV genome positive Burkitt´s Iymphoma and nasopharyngeal carcinoma Recently, however another category of EBV-related disease, ´chronic active EBV infection´, has been made to describe persons without a clearly defined underlying disease. We report 4 cases of patients, presented with episodic fever of unknown origin (FUO), who were diagnosed as severe chronic active EBV infection. A combined application of serology for EBV aud in-situ hybridization established the diagnosis of the EBV infection.
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KEYWORD
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epstein-barr virus, fever of unknown origin, severe chronic active epstein-barr virus infection
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